From GWAS to genome sequencing: complementary approaches to identify melanoma predisposition genes
نویسندگان
چکیده
From GWAS to genome sequencing: complementary approaches to identify melanoma predisposition genes S MacGregor, KM Brown, M Stark, M Gartside, S Woods, V Bonazzi, L Aoude, K Dutton-Regester, S Tyagi, J Liu, DL Duffy, J Palmer, A Cust, H Schmid, J Symmons, E Holland, C Agha-Hamilton, K Holohan, D Youngkin, E Gillanders, MA Jenkins, J Kelly, DC Whiteman, R Kefford, G Giles, B Armstrong, J Aitken, J Hopper, G Montgomery, C Schmidt, JM Trent, NG Martin, GJ Mann, NK Hayward
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Update on genetics of pre-eclampsia.
Over half of the familial predisposition to pre-eclampsia can be attributed to genetic factors in the mother and/or fetus. The search for genetic susceptibility variants has progressed through candidate gene studies, family-based linkage studies, and most recently genome-wide association studies (GWAS). It is unlikely that any single variant has a large effect on pre-eclampsia susceptibility; s...
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